Daily entries from the 17th century London diary
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Colonel William Sydenham had been an active officer during the Civil Wars, on the Parliament side; M.P. for Dorsetshire, Governor of Melcombe, and one of the Committee of Safety. He was the elder brother of the celebrated physician of that name.—B.
“Sydenham, [Col. William]”
That’s the name and spelling Robert Latham has in his index volume to the Latham & Matthews edition of the diary.
Sydenham/Syndenham appears once in the diary, according to the index. His brother doesn’t appear at all.